The accident happened just before 6 pm on Sunday northeast of Brömsebro in Torsås municipality.
Two people, one man and one woman in her 60s, were taken by ambulance to hospital. According to reports, the woman is critically injured and is still being cared for in hospitals.
The police have no suspicion of crime in connection with the accident.
While the rescue work was going on, there were traffic disruptions on the E22.