The blood of hibernating bears helps preserve muscle mass

The blood of hibernating bears helps preserve muscle mass

Black bears hibernate for seven months a year, yet during this time they retain their muscle mass and remain generally healthy.

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They hibernate most of the year, more exactly between five and seven months per year. The black bears are then in a state of controlled hypothermia: they lower their body temperaturedecrease their heart rate, fall into a kind of sleep lethargic and survive without eating or drinking. But even more, “they maintain their functions physical with a atrophy minimal skeletal muscle and metabolic dysfunction,” describes a study recently published in PLOS.

The study authors wondered what was in the blood of these bears that allowed them to keep so well. Because, for humans, such a state of lethargy for such a long duration inexorably leads to a significant loss of muscular mass. The Japanese team then carried out tests on muscle cells human skeletons, by injecting them with serum black bear blood, either collected during the active period or during hibernation. Then they waited and observed the effect on these cells.

An unknown factor in the blood

The result is there: the cells that received bear serum in hibernation have seen their content protein increase dramatically in 24 hours! Conversely, for those who received active bear serum, the natural process of muscle protein breakdown was not stopped. “We indicated that “a certain factor” present in the serum of hibernating bears can regulate the metabolism proteins in cultured human skeletal muscle cells and contribute to the maintenance of mass muscularconcludes physiologist Mitsunori Miyazaki of the University of Hiroshima. However, the identification of this factor has not yet been carried out”.

The researchers assume, however, that everything is at the level of ” I’inhibition of the protein degradation system”that is to say the proteolysis. In the future, they intend to focus on the formal identification of the mechanism at play with the blood serum of black bears. According to them, this would make it possible to develop “new approaches to prevent atrophy and weakness of skeletal muscles in man”.

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