Firefighters and specialists from Mexico and Venezuela are helping to fight the fire, which started when lightning struck an oil tanker.
One person has died in connection with the fire. At least 125 people have been injured, five of them seriously, and 14 firefighters are missing. Almost 5,000 residents nearby have been forced to evacuate.
Firefighters on site during Tuesday.
The fire is being fought with the help of airplanes, helicopters and boats, and the firefighters have also been able to deploy foam, something that was previously prevented by hot temperatures.
— These are not simple tasks. It is an intense and complex incident, says President Miguel Díaz-Canel.
The oil depot is important as it receives crude oil which is then transported to power plants to produce electricity. It is also a hub for imported heavy oil and diesel.