The Duke University study in mice revealed that women have an advantage at the molecular level, which protects them from a type of cell death that occurs in kidney damage.
The author of the study, Dr. “Kidney diseases affect more than 850 million people worldwide every year. So it’s important to understand why women’s kidneys are more protected from chronic and acute damage,” said Tomokazu Souma. used the phrase.
CAN BE A PIONEER IN THE TREATMENT OF RENAL DAMAGE
Souma said his findings could play an important role in the treatment of kidney damage in both sexes in the future.
The study focused on a type of cell death called ferroptosis, which occurs due to iron and oxidative stress, which has previously been discovered to play a key role in kidney diseases.
The researchers used a special type of genetic analysis method on mice. During the study, it was discovered that being female provides striking protection against ferroptosis in a special way.
Again, it was determined that this particular pathway is very active in women, and testosterone hormone in men decreases the activity of this pathway, which facilitates ferroptosis and undermines cell resistance in kidney damage.
The findings of the study were published November 8 in the journal Cell Reports. (AA)