The Medicines Agency warns of an increased risk of atrial fibrillation in patients taking anti-triglyceride treatments.
The Medicines Agency (ANSM) reports a “increased” risk of atrial or atrial fibrillation in patients suffering from cardiovascular diseases or presenting cardiovascular risk factors, and treated with ethyl esters of Omega-3 acids. When we talk about “atrial fibrillation” it is to designate thecardiac arrhythmia due to atrial fibrillation. This is a heart rhythm disorder which results in a succession of rapid, disordered heart contractions at the level of the atria of the heart. Concretely, the heartbeats are irregular and often fast. “It is a common heart disease and which can go unnoticed for a long time but whose The most serious consequences are the occurrence of a stroke. which can leave lifelong consequences.Dr Marc Druet, general practitioner, told us in a previous interview.
Dizziness, palpitations should alert
The medications targeted here are prescribed to lower triglyceride levels in the blood when diet and other non-drug measures have not been sufficient. They are in the form of 1g capsules of fatty acidsprescribed for adults and marketed under the names Lipidem®, Ysomega®, Omacor®, Mednutriflex Omega®… Warning: this is not just a warning. According to the ANSM, treatment must “to be permanently arrested” en case of occurrence of atrial fibrillation. The warning symptoms are:
- A feeling of dizziness
- A asthenia (great fatigue even after rest)
- Of the palpitations Or a feeling of tightness in the chest
- A shortness of breath
A higher risk beyond 4 grams per day
General practitioners, cardiologists, geriatricians, endocrinologists, specialists in internal medicine, community and hospital pharmacists must advise their patients to consult a doctor in the event of symptoms suggestive of atrial fibrillation. The risk of atrial fibrillation is higher with a dose of 4g/day. The European Medicines Agency (EMA) has recommended an update of the SmPC and the package leaflet for medicines based on ethyl esters of Omega-3 acids to take into account the risk of atrial fibrillation. The EMA also recommended including atrial fibrillation among the “common” side effects.
- Ethyl esters of Omega-3 acids: Increased and dose-dependent risk of atrial (or atrial) fibrillation in patients with cardiovascular diseases or presenting cardiovascular risk factors – ANSM, November 17, 2023