The fire is said to have started in some type of warehouse building in the district of Rothenburgsort and, according to the police, there is a risk that the smoke from the fire is toxic.
According to Hamburger Morgenpost more than 200 firefighters fight the fire. Local train and bus services are limited and Deutsche Bahn has canceled train services between Hamburg and Büchen.
140 people have been evacuated so far, Reuters reports.
The text is updated