After massively vaccinating the population against Covid, France is recalling. How much vaccine per vial? How many doses to keep your health pass? How much dose for Pfizer, Moderna, AstraZeneca or Janssen? Up-to-date info.
[Mise à jour le 26 novembre 2021 à 18h14] To extend theefficiency anti vaccines Covid Beyond 6 months, two doses are not enough. It is necessary to make a reminder. “The first dose does not induce a strong enough immune response in an immunologically “naive” individual, that is to say who has never encountered the microbe (virus, bacterium), ie the vast majority of the population in the case of the Sars-CoV-2 virus. Most vaccines are administered to children (first injections at the beginning of life) and require 3 or more injections to induce and sustainably maintain a level of immunity beyond a lasting protection threshold “, explains Cecil Czerkinsky, vaccinologist. The reminder opens on November 27 to all French people over the age of 18. The elderly and the most fragile are no longer the only ones concerned. the Reference vaccine for booster shots is Comirnaty® from Pfizer. It can be done regardless of age while the vaccine Moderna is reserved for over 30s (in primary vaccination and as a booster) since November 8 in accordance with the decision of the HAS. How much doses per vial vaccine? What amount of RNA with Pfizer and Moderna?
What is the quantity in ml of vaccine in a dose?
- a dose of Comirnaty vaccine Pfizer contains 0.3ml of saline solution including 30 micrograms of mRNA.
- a dose of Spikevax vaccine of Moderna contains 0.5ml of saline solution including 100 micrograms of RNA. For the vaccine booster, the amount is halved, i.e. 50 micrograms of RNA.
- one dose of AstraZeneca Vaxzevria vaccine contains 0.5 ml of the product.
- one dose of the Johnson & Johsnon Janssen vaccine contains 0.5 ml of the product.
How many doses in a vaccine vial?
The number of doses in a vial varies depending on the vaccine:
- Comirnaty® (Pfizer-BioNTech) : each vial contains 0.45 mL of product, i.e. 6 doses of 0.3 mL after dilution
- Spikevax (Moderna) : Each vial contains 10 doses of 0.5 mL.
- Vaxzevria (AstraZeneca / Oxford) : a bottle contains 8 doses of 0.5ml.
- Janssen COVID-19 vaccine : each 2.5ml bottle contains 5 doses of 0.5ml.
How many doses to be vaccinated?
As a primary vaccination, Comirnaty® vaccines (Pfizer-BioNTech), Vaxzevria (AstraZeneca / Oxford) and Spikevax (Moderna) require 2 doses of vaccine. A reminder is then to be done after 5 months if you want to keep your health pass.
How many doses of Pfizer vaccine should I make?
Two doses of the Comirnaty® vaccine from Pfizer-BioNTech should be given as a primary vaccination (0.3 ml each) then a booster dose while waiting at least 5 months (also 0.3 ml).
How many doses of Moderna vaccine?
Two doses of Moderna vaccine should be given as a primary vaccination (0.5ml each) then a booster dose (half-dose or 0.25 ml containing half the RNA than the first) while waiting at least 5 months.
How many doses for the AstraZeneca vaccine?
It is necessary to make two doses of the AstraZeneca vaccine (0.5ml each) then a booster dose (of Pfizer or Moderna (only for 30 years with this one)) while waiting at least 5 months.
How many doses for the Johnson & Johnson vaccine?
A dose of Janssen vaccine should be given Johnson & Johnson in primary vaccination (0.5 ml) then a second dose 4 weeks later (Pfizer or Moderna (only for 30 years with this one)).
What is the delay between the administration of two doses?
The time between the administration of the two doses varies depending on the vaccine:
Comirnaty® (Pfizer-BioNTech) : between 3 and 7 weeks.
Spikevax (Moderna) : between 3 and 7 weeks.
Vaxzevria (AstraZeneca / Oxford) : Between 9 and 12 weeks as recommended by the Haute Autorité de santé in its opinion of 1 March 2021, for people aged 55 and over.
Janssen COVID-19 vaccine : only one dose is necessary for primary vaccination.
What is the delay in getting the 3rd dose?
The 3rd dose of covid vaccine can be given 5 months after the second injection for people vaccinated with AstraZeneca, Pfizer and Moderna. The booster dose for people vaccinated with Janssen can be given 4 weeks after the first dose.
How many doses after being positive for Covid?
In accordance with the recommendation of the High Authority of Health in February 2021, a single dose of Covid vaccine is administered to people who have already been infected with the Covid-19 virus, as a primary vaccination. It is recommended to wait 2 months after testing positive for Covid-19 to get vaccinated. This dose acts as a “booster” for the immune system and is considered a second dose. After this first dose, these people should take a booster dose, considered the 3rd dose, at least 5 months after their injection.
What are the indications for a third dose?
As part of the vaccination campaign against Covid-19, the vaccine booster corresponds to the administration of an additional vaccine injection also called a “booster”. This booster dose is done with Pfizer vaccine regardless of age Where with the Moderna vaccine for populations over 30 years of age.
How many doses for the health pass?
Until December 15, a complete vaccination schedule is valid in France for the health pass:
- 7 days after the 2nd injection for double injection vaccines (Pfizer, Moderna, AstraZeneca) – 2 weeks to travel.
- 7 days after the injection for vaccines in people with a history of Covid (1 single injection) -2 weeks to travel.
- 4 weeks after injection for vaccines with a single injection (Johnson & Johnson).
From December 15th for people 65 years of age and over and those vaccinated with Janssen: a booster dose is mandatory to keep the health pass.
From January 15, 2022, all French people aged 18 to 64 who want to keep their health pass must also have had a booster dose (3 doses for those who received 2, 2 doses for those who had only one because they had had the covid before).
From now on, only 7 days will be enough to be considered as fully protected in France and to access the health pass. The European 14-day rules remain unchanged for the time being.
– Olivier Véran (@olivierveran) July 13, 2021
All the vaccines against Covid-19 used in France are recognized in the Member States of the European Union, recalls the government : Pfizer-BioNTech / Moderna / AstraZeneca / Johnson & Johnson / Janssen. Some Member States recognize other vaccines which have not yet received marketing authorization from the European Medicines Agency. It is up to the Member States to decide whether they will accept a vaccination certificate after a single dose or after a complete vaccination cycle. Most Member States recognize, however, that people who have recovered from Covid-19 and received a single dose of vaccine have followed a full vaccination course. All information by country of destination is available on: diplomatie.gouv.fr.
Sources:
Comirnaty: preparation and methods of injecting the vaccine. Ministry of Solidarity and Health. May 2021.
Covid-19 Vaccine Moderna: preparation and methods of injecting the vaccine. Ministry of Solidarity and Health. May 2021.
Various developments in the vaccination campaign, DGS, June 18, 2021.
Covid-19: TRODs to optimize the use of available vaccine doses. Press release posted on June 03, 2021, HAS.
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