After massively vaccinating the population against Covid, France is recalling. How much vaccine per vial? How many doses to keep your health pass? How much dose for Pfizer, Moderna, AstraZeneca or Janssen? Up-to-date info.
[Mise à jour le 5 janvier 2022 à 15h52] To extend theefficiency anti vaccines Covid Beyond 6 months, two doses are not enough. It is necessary to make a reminder. “The first dose does not induce a strong enough immune response in an immunologically “naive” individual, that is to say having never encountered the microbe (virus, bacterium), ie the vast majority of the population in the case of the Sars-CoV-2 virus. Most vaccines are administered to children (first injections at the beginning of life) and require 3 or more injections to induce and sustainably maintain a level of immunity beyond a lasting protection threshold “, explains Cecil Czerkinsky, vaccinologist. All French people aged 18 and over are affected by the booster dose if they want to keep their health pass. This reminder should be done in waiting at least 3 months after the last injection and at the end of a period of 4 additional months maximum (from February 15, 2022, this additional period will be reduced to 1 month). How much doses to have a complete vaccination schedule? In France ? How many dose of RNA per injection? Pfizer or Moderna?
How many doses of vaccine in France to be vaccinated?
As a primary vaccination, Comirnaty® vaccines (Pfizer-BioNTech), Vaxzevria (AstraZeneca / Oxford) and Spikevax (Moderna) require 2 doses of vaccine. A booster should then be done while waiting at least 3 months following the last injection. and at the end of a period of 4 additional months maximum (from February 15, 2022, this additional period will be 1 month against 4). The people who have had Covid and wish to be vaccinated do only one dose of vaccine as a primary vaccination, then a booster dose at least 3 months later. Otherwise, through their PCR or positive antigen test, they benefit from a 6-month recovery certificate recognized as a health pass.
If an infection occurs after a first Janssen injection:
- less than 15 days after: people receive an additional dose from 4 weeks and then a booster dose from 3 months after infection.
- more than 15 days after: people do not need to receive an additional dose and only receive a booster dose from 3 months after infection.
The people who had Covid-19 before their vaccination with Janssen receive a booster dose as early as 4 weeks after their injection.
How many doses of vaccine at 12 years old?
From 12 to 17 years old, the vaccination schedule is two doses of Pfizer vaccine. Adolescents in this age group are not affected by the vaccination booster to date unless they are immunocompromised or have a high-risk pathology or comorbidity. In this case, the booster dose can be administered after 3 months and is carried out with the Pfizer vaccine.
What is the quantity in ml of vaccine in a dose?
- a dose of Comirnaty vaccine Pfizer contains 0.3ml of saline solution including 30 micrograms of mRNA.
- a dose of Spikevax vaccine of Moderna contains 0.5ml of saline solution including 100 micrograms of RNA. For the vaccine booster, the amount is halved, i.e. 50 micrograms of RNA.
- one dose of AstraZeneca Vaxzevria vaccine contains 0.5 ml of the product.
- one dose of the Johnson & Johsnon Janssen vaccine contains 0.5 ml of the product.
How many doses in a vaccine vial?
The number of doses in a vial varies depending on the vaccine:
- Comirnaty® (Pfizer-BioNTech) : each vial contains 0.45 mL of product, i.e. 6 doses 0.3 mL after dilution
- Spikevax (Moderna) : each bottle contains 10 doses 0.5 mL.
- Vaxzevria (AstraZeneca / Oxford) : a bottle contains 8 doses of 0.5ml.
- Janssen COVID-19 vaccine : each 2.5ml bottle contains 5 doses of 0.5ml.
How many doses of Pfizer vaccine should I make?
Two doses of the Comirnaty® vaccine from Pfizer-BioNTech should be given as a primary vaccination (0.3 ml each) then a booster dose while waiting at least 3 months (also 0.3 ml).
How many doses of Moderna vaccine?
Two doses of Moderna vaccine should be given as a primary vaccination (0.5ml each) then a booster dose (half-dose or 0.25 ml containing half the RNA than the first) while waiting at least 3 months.
How many doses for the AstraZeneca vaccine?
It is necessary to make two doses of the AstraZeneca vaccine (0.5ml each) then a booster dose (of Pfizer or Moderna (only for 30 years with this one)) while waiting at least 3 months.
How many doses for the Johnson & Johnson vaccine?
A dose of Janssen vaccine should be given Johnson & Johnson in primary vaccination (0.5 ml) then a second dose 4 weeks later (Pfizer or Moderna (only for 30 years with this one)).
What is the delay between the administration of two doses?
The time between the administration of the two doses varies depending on the vaccine:
Comirnaty® (Pfizer-BioNTech) : between 3 and 7 weeks.
Spikevax (Moderna) : between 3 and 7 weeks.
Vaxzevria (AstraZeneca / Oxford) : Between 9 and 12 weeks as recommended by the Haute Autorité de santé in its opinion of 1 March 2021, for people aged 55 and over.
Janssen COVID-19 vaccine : only one dose is necessary for primary vaccination.
What is the deadline for doing a booster dose?
The booster dose (2nd or 3rd dose depending on the case) of covid vaccine can be given 3 months after the second injection for people vaccinated with AstraZeneca, Pfizer and Moderna. The booster dose for people vaccinated with Janssen can be given 4 weeks after the first dose.
How many doses after being positive for Covid?
In accordance with the recommendation of the High Authority of Health in February 2021, the people who have had Covid and wish to be vaccinated do only one dose of vaccine as a primary vaccination, then a booster dose at least 3 months later (or 4 weeks if the first vaccine was Janssen). Otherwise, through their PCR or positive antigen test, they benefit from a Covid recovery certificate valid for 6 months as a health pass.
How many doses for the health pass?
The health pass consists of the digital presentation (via the TousAntiCovid application) or paper, a sanitary proof, of which the vaccination provided that people have a complete vaccination schedule and the necessary time after the final injection, that is :
- 7 days after the 2nd injection for double injection vaccines (Pfizer, Moderna, AstraZeneca);
- 28 days after injection for vaccines with a single injection (Johnson & Johnson);
- 7 days after the injection for vaccines in people with a history of Covid (1 single injection).
Since December 15, 2021, the rules relating to the health pass have changed only for people aged 65 and over, and people vaccinated with Janssen. These people must have made their recall, from the moment when they are eligible (i.e. 3 months after their last injection for the first and 1 month for the second), and at the end of a period of 4 additional months maximum for the first and 1 month for the second. From February 15, 2022, French people over 18 years old must have taken their booster dose to keep their health pass (at least 3 months after the last injection and up to 1 month more).
All the Covid-19 vaccines used in France are recognized in the Member States of the European Union, recalls the government : Pfizer-BioNTech / Moderna / AstraZeneca / Johnson & Johnson / Janssen. Some Member States recognize other vaccines which have not yet received marketing authorization from the European Medicines Agency. It is up to the Member States to decide whether they will accept a vaccination certificate after a single dose or after a complete vaccination cycle. Most Member States recognize, however, that people who have recovered from Covid-19 and received a single dose of the vaccine have followed a full vaccination course. All information by country of destination is available on: diplomatie.gouv.fr.
Sources:
Comirnaty: preparation and methods of injecting the vaccine. Ministry of Solidarity and Health. May 2021.
Covid-19 Vaccine Moderna: preparation and methods of injecting the vaccine. Ministry of Solidarity and Health. May 2021.
Various developments in the vaccination campaign, DGS, June 18, 2021.
Covid-19: TRODs to optimize the use of available vaccine doses. Press release posted on June 03, 2021, HAS.
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