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Since the start of anti-covid vaccination, appendicitis has been one of the adverse effects of messenger RNA vaccines. A Danish study sought to assess the potential link between vaccination against Covid-19 and appendicitis. According to their results, there would be no demonstrated link.
When the Pfizer laboratory’s Covid-19 vaccine trials showed a higher number of appendicitis cases in the vaccinated groups, the American Medicines Agency (FDA) decided to add appendicitis to the list of adverse effects.
To assess this risk, Danish researchers compared the risk of appendicitis in people vaccinated against Covid-19 with a messenger RNA vaccine and in unvaccinated people, both groups having been infected with Covid-19. The results were published in the medical journal JAMA Internal Medicine end of April.
Two groups, one difference: vaccination
Both groups were made up of individuals aged 12 and over who had all contracted Covid-19. The only difference: the second group had not gone through the anti-covid vaccination box.
The group of vaccinated individuals had received either the Pfizer vaccine or the Moderna vaccine.
The study was conducted from December 27, 2020 to November 30, 2021 and participants were followed for 21 days. It excluded patients who had already had appendicitis or an appendectomy, individuals vaccinated with a vaccine without messenger RNA and those who had already had Covid-19 before being included in the study.
Individuals in the unvaccinated groups were removed from the study if they were vaccinated against Covid-19 during follow-up.
No link between appendicitis and vaccination
“In this national study including 4 million vaccinated people, we found no association between immunization with mRNA-based Covid-19 vaccines and appendicitis”say the researchers.
The researchers specified that the results of the study had been adjusted, in particular according to the age, the sex, or even the medical history of the patients.
Of the 4,048,883 vaccinated individuals, 330 had appendicitis within 21 days of the first dose of a messenger RNA vaccine, representing 8.1 episodes per 100,000 vaccinated individuals. After the second dose, there were 340 cases of appendicitis among 3,944,408 patients (rate of 8.6 per 100,000 individuals).
After comparing the results of the vaccinated and unvaccinated groups, the researchers found that there was no increased risk of appendicitis after vaccination. The result was identical regardless of age, sex and type of vaccine.
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Results still to be confirmed
The Danish scientists nevertheless insisted that the study had its own limitations, in particular since it did not detect possible risks of appendicitis beyond the predefined risk interval – of 21 days.
“Further studies conducted in different settings will be needed to completely rule out appendicitis as a safety issue related to Covid-19 mRNA vaccination”they concluded.