According to the Haaretz newspaper, several gunmen opened fire on the car near the checkpoint.
Three Israelis have died when their car came under fire in the occupied West Bank.
Israeli Haaretz magazine said several gunmen opened fire on a car near the Tarqumiyah checkpoint near the city of Hebron.
of The Times of Israel two of the victims were around 30 years old and one was around 50 years old.
Security forces are looking for the attackers.
Updated 1.9. at 9:38 the number of dead.
Reuters, AFP