The report, published in Nature Medicine, revealed that excessive amounts of the vitamin, found in many foods including meat, fish, nuts, fortified cereals and breads, pose a previously unknown risk. The recommended daily amount of niacin for men is 16 milligrams per day and 14 milligrams per day for women who are not pregnant. The study’s senior author, MD, is chief of cardiovascular and metabolic sciences at Cleveland Clinic’s Lerner Research Institute and chief of preventive cardiology at Heart. About 1 in 4 Americans has higher than recommended levels of niacin, Stanley Hazen said.
Researchers don’t currently know where to draw the line between healthy and unhealthy amounts of niacin, but that may be determined through future research, NBC News reported. . “Since we have reason to believe that taking too much niacin may potentially lead to an increased risk of developing cardiovascular disease, the average person should avoid niacin supplements,” Hazen says. ” said.
Hazen says flour, grains and grains have been enriched with niacin since the 1940s, after scientists discovered that very low nutrient levels could lead to a potentially fatal condition called pellagra. from cultivation He said that Americans currently get plenty of niacin from their diets. Before the development of cholesterol-lowering statins, niacin supplements were once prescribed by doctors to improve cholesterol levels.
In order to investigate unknown risk factors for cardiovascular disease, Hazen and his colleagues took medical records from 1,162 patients who came to the cardiology center to be evaluated for heart disease. §lı k designed a multi-part study that included analysis of blood samples. Researchers were looking for common markers or signs in patients’ blood that could reveal new risk factors.
The research resulted in the discovery of a substance in some blood samples that is only produced when there is excess niacin. This finding led to two additional “validation” studies that included data from a total of 3,163 adults with or suspected of having heart disease. Two studies, one in the United States and the other in Europe, found that the niacin breakdown product 4PY prevented participants’ future risk of heart attack, stroke, and death. He showed that he was dying.
The last part of the study involved experiments on mice. Inflammation in blood vessels increased when rodents were injected with 4PY. Dr. D., director of metabolism and lipids at Mount Sinai Health System in New York City. Robert Rosenson said the results were “fascinating” and “important”. He added that the new pathway to heart disease could lead to the discovery of a drug that could reduce blood vessel inflammation and reduce the likelihood of major cardiovascular events.