Sibutramine: name, dangers, withdrawn from the market?

Sibutramine was originally prescribed to treat obesity. It worked by changing the levels of serotonin and norepinephrine, chemicals that play a role in a role in regulating appetite and metabolism. However, sibutramine has been withdrawn from the market in many countries, including Francedue to security concerns.

Why take sibutramine?

When it was available on the French market, sibutramine “acted like a serotonin reuptake inhibitor and norepinephrine in the brainexplains Raoul Santucci, pharmacist. Neurotransmitters involved in the regulation of appetite and metabolism. By increasing the availability of these neurotransmitters, sibutramine may help reduce appetite and promote feelings of fullness, which can lead to a reduction in food intake and, consequently, weight loss“. This medication was prescribed in addition toA low-calorie diet and regular sports practice. It was intended for obese patients (with a BMI > 30 kg/m) or overweight (with a BMI > 27 kg/m) and presenting at least a risk factor such as diabetes or dyslipidemia (cholesterol).

Trade names of medicines containing sibutramine

Sibutramine was marketed in France under the name Sibutral®, replies the pharmacist. She obtained its marketing authorization in 2001 then was withdrawn from the market in 2010.

Is it still available in France?

“Sibutramine was withdrawn from the market in France in 2010, as it was in many European countries. continues our interlocutor.

Why was sibutramine taken off the market?

Sibutramine has been withdrawn from the market in many countries due to serious safety concerns. “Studies have shown that the use of sibutramine can increase the risk of cardiovascular problems such as strokes (Stroke) and the heart attackespecially in people with a history of cardiovascular disease”, explains the healthcare professional. Additionally, the potential benefits of sibutramine in terms of weight loss were considered less important than the risks associated with cardiovascular problems. “Several scientific committees have noted weight loss ranging from 2 to 4 kilos under sibutramine versus placebo and without maintenance over time. The effect of the drug was therefore moderate,” he continues.

What are the side effects ?

Sibutramine, before its withdrawal from the market, was associated with several side effects. “We can cite headaches, dry mouth, insomnia and constipation“, concludes Raoul Santucci. In certain cases, sibutramine could cause an increase in blood pressurewhich could be of particular concern for people with a history of cardiovascular problems.

Thanks to Raoul Santucci, pharmacist at the Clinique de l’Orangerie (Elsan) in Strasbourg.