Alzheimer’s: promising results for a new treatment

Alzheimers promising results for a new treatment

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    According to a press release from Eli Lilly on May 3, a treatment developed by the laboratory would have succeeded in slowing the cognitive decline linked to Alzheimer’s disease in the context of a large clinical trial.

    These results were greeted with enthusiasm by experts, who hailed the entry into a “new era” for the management of Alzheimer’s disease, thanks to several recent breakthroughs.

    “The Age of Alzheimer’s Treatment”

    The clinical trial, which included 1,200 participants who had not yet reached advanced disease, showed a 35% reduction in cognitive decline in patients treated with donanemab, according to a company statement.

    Eli Lilly plans to file for FDA approval as early as this quarter, and globally.”as fast as possible“However, the treatment can lead to serious side effects, such as edema or cerebral hemorrhage. Three participants in the clinical trial died.

    The clinical trial also measured the ability to perform everyday tasks, such as driving, conversing, having hobbies or managing finances. Over 18 months, participants who received the treatment showed a 40% reduction in decline in their ability to perform these tasks.

    “These results confirm that we are entering the era of Alzheimer’s treatment”rejoiced Catherine Mummery, of the National Hospital for Neurology and Neurosurgery in London.

    Recently approved treatments

    It will now be possible “to realistically expect to be able to treat and stabilize a person with Alzheimer’s disease, with long-term management, rather than palliative and supportive care”she added.

    Research in the fight against Alzheimer’s disease has stagnated for decades. But two new treatments, developed by the Japanese pharmaceutical companies Eisai and the American Biogen, have recently been approved in the United States: Leqembi (whose active ingredient is called lecanemab), and Aduhelm (aducanumab molecule).

    If the authorization of Aduhelm was controversial, some experts pointing to the lack of evidence on its effectiveness, lecanemab was the first to demonstrate a reduction in cognitive decline (by 27%) in the context of a clinical trial.

    Eli Lilly’s treatment, if any “approved alongside lecanemab”could “provide a choice of treatments to patients”welcomed Liz Coulthard, of the University of Bristol.

    Alzheimer’s disease affects tens of millions of people worldwide.


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